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    Accelrys rna composer
    Rna Composer, supplied by Accelrys, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rna+composer/pm41419059-72-7-13?v=Accelrys
    Average 86 stars, based on 1 article reviews
    rna composer - by Bioz Stars, 2026-08
    86/100 stars

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    Image Search Results


    Examples of the most representative (not all) clinical trials (completed or ongoing) using different types of nanosystems for melanoma treatment.

    Journal: Pharmaceutics

    Article Title: How to Treat Melanoma? The Current Status of Innovative Nanotechnological Strategies and the Role of Minimally Invasive Approaches like PTT and PDT

    doi: 10.3390/pharmaceutics14091817

    Figure Lengend Snippet: Examples of the most representative (not all) clinical trials (completed or ongoing) using different types of nanosystems for melanoma treatment.

    Article Snippet: , Safety and tolerability of a cancer vaccine composed by naked RNA-drug products in a liposomal formulation (Lipo-MERIT). , IIIB/C/IV , BioNTech SE , March 2015 , May 2023 , NCT02410733.

    Techniques:

    Schematic illustration of the proposed mechanism, by which serinol nucleic acid (SNA)-substituted small interfering RNA (siRNA) reduces off-target activity. In pre-RNA-induced silencing complex (pre-RISC), an interaction between the 5’ terminus of one strand and the MID domain results in selection of that strand for the formation of RISC. Off-target effects can occur if the passenger strand is selected. The presence of the SNA moiety at the 5’ terminus of the passenger strand inhibits the interaction with Argonaute 2 (AGO2)-MID, reducing off-target effects.

    Journal: International Journal of Molecular Sciences

    Article Title: Investigation of Strand-Selective Interaction of SNA-Modified siRNA with AGO2-MID

    doi: 10.3390/ijms21155218

    Figure Lengend Snippet: Schematic illustration of the proposed mechanism, by which serinol nucleic acid (SNA)-substituted small interfering RNA (siRNA) reduces off-target activity. In pre-RNA-induced silencing complex (pre-RISC), an interaction between the 5’ terminus of one strand and the MID domain results in selection of that strand for the formation of RISC. Off-target effects can occur if the passenger strand is selected. The presence of the SNA moiety at the 5’ terminus of the passenger strand inhibits the interaction with Argonaute 2 (AGO2)-MID, reducing off-target effects.

    Article Snippet: The RNA oligonucleotides and oligonucleotides composed of SNA and RNA were acquired from Hokkaido System Science Co., Ltd. (Sapporo, Japan).

    Techniques: Small Interfering RNA, Activity Assay, Selection

    Isothermal calorimetry (ITC) analyses of the binding between AGO2-MID and mono- or dinucleotides. ( a ) Chemical structures of RNA and SNA mononucleotides. ( b ) ITC profiles of the binding between AGO2-MID and mono- and dinucleotides with or without terminal phosphate groups. ITC experiments were performed at 25 °C in 25 mM MES (pH 6.5), 200 mM NaCl, 1 mM tris(2-carboxyethyl)phosphine (TCEP). For each experiment, 20 μM AGO2-MID was loaded into the sample cell.

    Journal: International Journal of Molecular Sciences

    Article Title: Investigation of Strand-Selective Interaction of SNA-Modified siRNA with AGO2-MID

    doi: 10.3390/ijms21155218

    Figure Lengend Snippet: Isothermal calorimetry (ITC) analyses of the binding between AGO2-MID and mono- or dinucleotides. ( a ) Chemical structures of RNA and SNA mononucleotides. ( b ) ITC profiles of the binding between AGO2-MID and mono- and dinucleotides with or without terminal phosphate groups. ITC experiments were performed at 25 °C in 25 mM MES (pH 6.5), 200 mM NaCl, 1 mM tris(2-carboxyethyl)phosphine (TCEP). For each experiment, 20 μM AGO2-MID was loaded into the sample cell.

    Article Snippet: The RNA oligonucleotides and oligonucleotides composed of SNA and RNA were acquired from Hokkaido System Science Co., Ltd. (Sapporo, Japan).

    Techniques: Binding Assay

    RNA interference (RNAi) activities of SNA-modified siRNAs. ( a ) siRNAs used in the luciferase assay. The upper strand is the passenger strand (P) and the lower strand is the guide strand (G). Bold, italic characters indicate SNA and p denotes 5’ phosphate. ( b ) RNAi activities of the guide strands (grey bars) and passenger strands (cyan bars) evaluated using reporter plasmids pGL3-On and pGL3-Off, respectively. Plotted are means and SD ( n = 3) of firefly /Renilla luciferase signal relative to the untreated sample. ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. native P/G.

    Journal: International Journal of Molecular Sciences

    Article Title: Investigation of Strand-Selective Interaction of SNA-Modified siRNA with AGO2-MID

    doi: 10.3390/ijms21155218

    Figure Lengend Snippet: RNA interference (RNAi) activities of SNA-modified siRNAs. ( a ) siRNAs used in the luciferase assay. The upper strand is the passenger strand (P) and the lower strand is the guide strand (G). Bold, italic characters indicate SNA and p denotes 5’ phosphate. ( b ) RNAi activities of the guide strands (grey bars) and passenger strands (cyan bars) evaluated using reporter plasmids pGL3-On and pGL3-Off, respectively. Plotted are means and SD ( n = 3) of firefly /Renilla luciferase signal relative to the untreated sample. ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. native P/G.

    Article Snippet: The RNA oligonucleotides and oligonucleotides composed of SNA and RNA were acquired from Hokkaido System Science Co., Ltd. (Sapporo, Japan).

    Techniques: Modification, Luciferase